Some observations on classical QSAR
نویسندگان
چکیده
منابع مشابه
Some observations on classical QSAR
Classical QSAR began almost 30 years ago. This article briefly traces its development, use and impact in relation to drug design and medicinal chemistry. Particular aspects discussed include hydrophobicity, relative potency in a series, tissue selectivity, central nervous system penetration, pharmacokinetics, potency optimization, bioisosterism, mechanistic insights, synthesis termination, rece...
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Sir,?I am not attempting in this letter to give any elaborate or comprehensive history of the disease, nor do I consider it necessary to tire my readers by a repetition of its etiology, symptoms or pathological manifestations so ably and voluminously narrated in any good text-book of medicine. I shall only give, in brief, a few features of this disease that came to my notice in the recent epide...
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ژورنال
عنوان ژورنال: Perspectives in Drug Discovery and Design
سال: 1993
ISSN: 0928-2866,1573-9023
DOI: 10.1007/bf02174527